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Integrative Biology: cancer modelling

Contact:
Dr Eamonn Gaffney
School of Mathematics
The University of Birmingham
Edgbaston, Birmingham
B15 2TT, United Kingdom

Email: informatics-crn-enquiries[at]cs.bham.ac.uk
Website: http://www.integrativebiology.ox.ac.uk/

The Integrative Biology Project is an international, multi-institutional, multi-disciplinary project that will demonstrate the crucial role of e-Science in facilitating large-scale collaborative research for modelling within the biomedical sciences, with a particular focus on heart disease and cancer.

The goal of the project is to build a Grid-enabled development platform for integrative biological modelling. This platform will allow clinicians and biologists to perform in-silico testing and development of novel experimental approaches, concentrating in this development phase on two major disease areas: cardiovascular disease and cancer. The computational infrastructure will include simulation tools allowing assimilation and synthesis of data, parameter estimation, computational steering, and visualisation of complex simulated data.

In cancer, it will be possible to grow virtual tumours, through the crucial stages of early development. In whole-heart modelling the clinician will be able to explore in-silico the likely causes of commonly occurring heart conditions. For both disease areas, it will be possible to test the actions of new drugs, and design and optimise alternative treatment protocols such as multiple-drug therapies, supporting the drive towards patient-centred care regimes. Birmingham is primarily involved in cancer modelling, and specifically cellular development of colorectal cancer and investigating the design and optimisation of novel cancer chemotherapeutic protocols of potential clinical relevance.